Function of Deptor and its roles in hematological malignancies

Deptor is a protein that interacts with mTOR and belongs to the mTORC1 mTORC2 complexes. capable of inhibiting kinase activity mTOR. It well known pathway involved in various signaling pathways are biological processes such as cell growth, apoptosis, autophagy, ER stress response. Therefore, Deptor, being natural inhibitor mTOR, has become very important its study. Because this, it research role regarding development progression human malignancies, especially hematologic malignancies. Due variation expression cancer, been suggested can act an oncogene or tumor suppressor depending on cellular tissue context. This review discusses recent advances transcriptional post-transcriptional regulation Deptor. As activities hematological possible biomarker, clinical relevance these